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Conivaptan

Generic name: conivaptan [ koe-NYE-vap-tan ]
Brand name: Vaprisol
Dosage form: intravenous solution (20 mg/100 mL-D5%)
Drug class: Vasopressin antagonists

Medically reviewed by Drugs.com on Jan 29, 2024. Written by Cerner Multum.

What is conivaptan?

Conivaptan reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that results in low sodium levels and fluid retention.

Conivaptan is used to treat hyponatremia (low sodium levels). Conivaptan improves urine flow without causing the body to lose too much sodium as you urinate.

Conivaptan may also be used for purposes not listed in this medication guide.

Conivaptan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have:

Common side effects of conivaptan may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not receive conivaptan if you are allergic to corn products, or if you are unable to urinate.

Serious drug interactions can occur when certain medicines are used together. Tell your doctor about all your current medicines and any you start or stop using.

Before taking this medicine

You should not receive conivaptan if you are allergic to corn products, or if you are unable to urinate.

Some medicines can cause unwanted or dangerous effects when used with conivaptan. Your doctor may need to change your treatment plan if you use any of the following drugs:

To make sure conivaptan is safe for you, tell your doctor if you have:

It is not known whether conivaptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine may affect fertility (ability to have children) in women.

It is not known whether conivaptan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving conivaptan.

How is conivaptan given?

Conivaptan is injected into a vein through an IV. You will receive this injection in a hospital setting.

Conivaptan is infused around-the-clock for 2 to 4 days. This medication is usually given only in a hospital.

You may have very low blood pressure while taking this medicine. Tell your caregivers if you feel weak, tired, dizzy, or very light-headed, or if you have any diarrhea or vomiting.

Because conivaptan can irritate the skin or vein when the medicine enters the body, your IV needle will be moved to a different vein every 24 hours.

To be sure this medicine is helping your condition, your blood will need to be tested often.

Conivaptan dosing information

Usual Adult Dose for Hyponatremia:

Initial dose: Loading dose of 20 mg IV once over 30 minutes; followed by 20 mg continuous IV infusion over 24 hours
-Following initial day of treatment, administer 20 mg continuous IV infusion over 24 hours for an additional 1 to 3 days; may titrate to a maximum of 40 mg continuous IV infusion over 24 hours if serum sodium is not rising at the desired rate

Comments:
-The total duration of infusion (after the loading dose) should not exceed 4 days.
-Frequently monitor serum sodium and volume status during administration.

Use: To raise serum sodium in hospitalized patients with euvolemic or hypervolemic hyponatremia

Usual Adult Dose for Hyponatremia, euvolemic:

Initial dose: Loading dose of 20 mg IV once over 30 minutes; followed by 20 mg continuous IV infusion over 24 hours
-Following initial day of treatment, administer 20 mg continuous IV infusion over 24 hours for an additional 1 to 3 days; may titrate to a maximum of 40 mg continuous IV infusion over 24 hours if serum sodium is not rising at the desired rate

Comments:
-The total duration of infusion (after the loading dose) should not exceed 4 days.
-Frequently monitor serum sodium and volume status during administration.

Use: To raise serum sodium in hospitalized patients with euvolemic or hypervolemic hyponatremia

What happens if I miss a dose?

Since conivaptan is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Since conivaptan is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving conivaptan?

Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What other drugs will affect conivaptan?

Many drugs can interact with conivaptan, and some drugs should not be used together. You may need to wait at least 1 week after your last dose of conivaptan before you can begin taking certain other medicines. Ask your doctor about your specific treatment plan.

Not all possible interactions are listed in this medication guide. Tell your doctor about all your medications and any you start or stop using during treatment with conivaptan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.